The draw for the quarter finals of the 2015/16 Greek Football Cup took place at the central offices of the Hellenic Football Federation (EPO) on Friday without, however, yielding any classic derbies. The pairs are as follows:
- Panionios v PAOK
- Olympiacos v Asteras Tripolis
- AEK v Iraklis
- Panathinaikos v Atromitos
The first matches in the knock-out round will take place on the 27th and 28th of January, with the rematches scheduled for the 3rd, 4th, 11th and 12th of February.